If you want to route emils from PowerMTA though another SMTP server, you can use following config.
In this example, all outgoing emails to @outlook.com domain will get routed through Amazon SES.
Edit PowerMTA config file
vi /etc/pmta/config
Add folowing
queue-to amazon-ses.route
auth-username USER_NAME_HERE
auth-password PASSWORD_HERE
route email-smtp.us-west-2.amazonaws.com:587
use-starttls yes
require-starttls yes
Restart PowerMTA
systemctl restart pmta
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